When six-year-old Sophie is tragically orphaned guardianship is assigned to her estranged aunt Annabelle. The two move into a large, eerie, Victorian house where Sophie unearths a locked wooden box with a strange symbol drawn on it. Desperate to connect with her niece Annabelle pries the lock open revealing a beautiful music box. Each time the music box is wound and replayed it's surprisingly chilling melody plays slightly longer, captivating Sophie even more. When the music box begins affecting Sophie's behavior and health Annabelle seeks the aid of a child psychologist and clairvoyant who soon discover the music box is possessed by an evil spirit who seeks to haunt Sophie and destroy Annabelle. As the haunting intensifies time begins to run out and Annabelle finds herself racing against the music box's melody to defeat the spirit before the last note plays.</p>...
本片根据纽约市的英籍神经医师奥利佛·萨克斯（Oliver Sacks）的同名回忆录改编。1969年，羞怯内向但对实验充满热忱的脑科医生马尔科姆·塞尔（罗宾·威廉姆斯 Robin Williams 饰）来到纽约市布朗克斯区一家医院，对院内的强直性昏厥证患者进行治疗。在护士埃莉诺（朱莉·卡夫娜 Julie Kavner 饰）的帮助和鼓励下，塞尔医生对病人大胆用药，使一群昏厥几十年的患者重获新生，尤其对患者伦纳德·洛（罗伯特·德尼罗 Robert De Niro）效果尤为明显。但令人意外的是，患者们在苏醒后不久，又纷纷出现了病情恶化的趋势……...
